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  • Abbokinase Information

  • Abbokinase Information


    Abbokinase is a thrombolytic agent. The primary active ingredient in Abbokinase is urokinase, which is an enzyme collected from neonatal kidneys. These kidneys have been donated from neonatals (infants between 0 and 28 days) whose cause of death was not due to infection or infectious diseases. No fetal tissue is used in the making of this product. Urokinase can also be found in urine as well. Abbokinase is a white powder which is also mixed with mannitol, Albumin, and sodium chloride, and is reconstituted with Sterile Water for injection.


    Abbokinase is used to treat acute pulmonary emboli, which is when there is a blockage, or blood clot, obstructing one or more lobes of the heart. It is also used in patients whose pulmonary emboli are complicated by unstable hemodynamics. This means that the patient fails to maintain blood pressure without supportive means.


    Abbokinase should not be used by patients with active internal bleeding, recent head trauma or intracranial or intraspinal surgery, and severe hypertension.

    Possible Side Effects

    More common

    Bleeding or oozing from cuts, gums, wounds, or around the place of injection; fever; low blood pressure

    Less common or rare

    Bruising; changes in facial skin color; confusion; double vision; fast or irregular breathing; flushing or redness of skin; headache (mild); muscle pain (mild); nausea; shortness of breath, troubled breathing, tightness in chest, and/or wheezing; skin rash, hives, or itching; swelling of eyes, face, lips, or tongue; trouble in speaking; weakness in arms or legs

    Symptoms of bleeding inside the body

    Abdominal or stomach pain or swelling; back pain or backaches; blood in urine; bloody or black, tarry stools; constipation; coughing up blood; dizziness; headaches (sudden, severe, or continuing); joint pain, stiffness, or swelling; muscle pain or stiffness (severe or continuing); nosebleeds; unexpected or unusually heavy bleeding from vagina; vomiting of blood or material that looks like coffee grounds

    Possible Interactions

    Before you receive Abbokinase, it is especially important that your doctor know if you are taking any of the following:

    Anticoagulants (blood thinners); Aspirin; Cefamandole (e.g., Mandol); Cefoperazone (e.g., Cefobid); Cefotetan (e.g., Cefotan); Divalproex (e.g., Depakote); Enoxaparin (e.g., Lovenox); Heparin or Indomethacin (e.g., Indocin); Inflammation or pain medicine (except narcotics); Phenylbutazone (e.g., Butazolidin); Plicamycin (e.g., Mithracin); Sulfinpyrazone (e.g., Anturane); Ticlopidine (e.g., Ticlid); Valproic acid (e.g., Depakene)

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