Selected Vegetables - Sun's Soup History Selected Vegetables/Sun’s Soup was first conceived as a treatment for cancer in the mid-1980s. In an effort to help a relative who was diagnosed with stage IV non-small cell lung cancer (metastasis to the left adrenal gland), the developer created a mixture that contained shiitake mushroom, mung bean, Hedyotis diffusa, and Scutellaria barbata in the belief that these plant materials had anticancer and/or immune-system–stimulating properties.[1-3] After the relative appeared to benefit from this treatment (the relative was reported to be alive and cancer free more than 13 years later [3] ), 3 additional patients (1 with stage IV kidney cancer that had metastasized to the lungs, 1 with stage IV kidney cancer that had metastasized to the liver and to the lungs, and 1 with stage IV non-small cell lung cancer that had metastasized to the brain) were treated with a variant of the original mixture, i.e., a combination of shiitake mushroom and mung bean.[1] (Note: No explanation has been given for the omission of Hedyotis diffusa and Scutellaria barbata for these patients.) These additional patients were also said to benefit from vegetable/herb treatment.[1] (See Human/Clinical Studies.) In June 1992, the developer filed a patent application for the “Herbal treatment of malignancy,” and a patent was awarded in August 1995.[1] Also in June 1992, the developer initiated a clinical trial in the Czech Republic to test Selected Vegetables/Sun’s Soup as a treatment for advanced non-small cell lung cancer.[4] A second clinical study (a nonconsecutive case series) that also involved patients with advanced non-small cell lung cancer was completed in 1997.[5] It is unclear, however, when patient accrual for this second study began.[5] In both reports of the clinical study results, the authors concluded that patients who received Selected Vegetables/Sun’s Soup had prolonged survival.[4,5] (See Human/Clinical Studies.) In 1998, the developer reported at a scientific conference that additional patients with various other types of cancer had benefited from treatment with Selected Vegetables/Sun’s Soup.[2] (See Human/Clinical Studies.) As noted previously (General Information), the proposed mechanism of action for Selected Vegetables/Sun’s Soup involves anticancer and/or immune-system–stimulating activities associated with some of the ingredients. Reviewed in [1-5] The following types of compounds likely found in Selected Vegetables/Sun’s Soup have been investigated for these activities: protease inhibitors and autoclave-resistant factor, which are found in soybeans; plant sterols; saponin; inositol hexaphosphate (IP6); beta-glucans; lectins; coumestans such as coumestrol; and isoflavones such as daidzein, genistein, and biochanin A. Reviewed in [4,5] One beta-glucan found in shiitake mushroom, i.e., lentinan, has been used as an adjunctive therapy for cancer (primarily gastric cancer and colorectal cancer) in Japan.[6,7] Reviewed in [8,9] Treatment with lentinan has been reported to prolong the survival of patients with gastric cancer [6,7] Reviewed in [8,9] and to improve their quality of life.[6] However, lentinan may not be an active component in Selected Vegetables/Sun’s Soup. This compound has a large molecular mass and is believed to have only limited oral bioavailability. Reviewed in [8-10] Therefore, lentinan has usually been given by intravenous injection. Nonetheless, other substances in shiitake mushroom have been identified as having greater oral bioavailability, and these substances have shown anticancer activity in animal experiments. Reviewed in [8,10] References Sun AS: Herbal Treatment of Malignancy. US Patent 5437866. August 1, 1995. Washington, DC: US Patent and Trademark Office, 1995. Available online. Last accessed June 21, 2004. Sun A: Food therapy for non-small cell lung cancer. In: Comprehensive Cancer Care: Integrating Complementary and Alternative Therapies - A Conference for Health professionals, June 12-14, 1998. Breakout Session 405: Herbal Therapies. Available online. Last accessed June 21, 2004. Cancer Advisory Panel for Complementary and Alternative Medicine (CAPCAM).: Minutes of the First Meeting - July 8-9, 1999: Section X: Phase I/II study of stage III and IV non-small cell lung cancer patients taking a specific dietary supplement - Dr. Alexander Sun, Medical Director, Connecticut Institute of Aging and Cancer. Bethesda, Md: National Center for Complementary and Alternative Medicine, 2002. Available online. Last accessed June 21, 2004. Sun AS, Ostadal O, Ryznar V, et al.: Phase I/II study of stage III and IV non-small cell lung cancer patients taking a specific dietary supplement. Nutr Cancer 34 (1): 62-9, 1999. [PUBMED Abstract] Sun AS, Yeh HC, Wang LH, et al.: Pilot study of a specific dietary supplement in tumor-bearing mice and in stage IIIB and IV non-small cell lung cancer patients. Nutr Cancer 39 (1): 85-95, 2001. [PUBMED Abstract] Nakano H, Namatame K, Nemoto H, et al.: A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group. Hepatogastroenterology 46 (28): 2662-8, 1999 Jul-Aug. [PUBMED Abstract] Taguchi T: Clinical efficacy of lentinan on patients with stomach cancer: end point results of a four-year follow-up survey. Cancer Detect Prev Suppl 1: 333-49, 1987. [PUBMED Abstract] Borchers AT, Stern JS, Hackman RM, et al.: Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med 221 (4): 281-93, 1999. [PUBMED Abstract] Kidd PM: The use of mushroom glucans and proteoglycans in cancer treatment. Altern Med Rev 5 (1): 4-27, 2000. [PUBMED Abstract] Wasser SP, Weis AL: Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol 19 (1): 65-96, 1999. [PUBMED Abstract] Read More On This Subject

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